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UMAMI FUNCTIONAL PALATABILITY ENHANCER IMPROVED GROWTH, INTESTINAL MORPHOLOGY AND HEPATOPANCREAS PROTEASE ACTIVITY OF WHITE SHRIMP (PENAEUS VANNAMEI), IN PARTIAL OR TOTAL SUBSTITUTION OF SQUID PASTE

Crustaceans have highly evolved chemosensory systems which help them detect and find food items in environments with low visibility and rich in dissolved chemicals. Attractants are commonly used in shrimp farming to promote a quick identification and consumption of the feeds. These are usually fishery by-products (e.g., fish, squid or…

FEEDING STIMULATION ABILITY AND CENTRAL EFFECTS OF INTRAPERITONEAL TREATMENT OF L-LEUCINE, L-VALINE, AND L-PROLINE ON AMINO ACID SENSING SYSTEMS IN RAINBOW TROUT: IMPLICATION IN FOOD INTAKE CONTROL

To continue gathering knowledge on the central regulation of food intake in response to amino acids in teleost fish, using as a model rainbow trout (Oncorhynchus mykiss), we evaluated in a first experiment the feeding attractiveness of l-leucine, l-valine, and l-proline offered as an agar gel matrix. In a second…

ANTIMICROBIAL PROMOTION OF PIG GROWTH IS ASSOCIATED WITH TISSUE-SPECIFIC REMODELING OF BILE ACID SIGNATURE AND SIGNALING

The spread of bacterial resistance to antimicrobials (AMA) have intensified efforts to discontinue the non-therapeutic use of AMA in animal production. Finding alternatives to AMA, however, is currently encumbered by the obscure mechanism that underlies their growth-promoting action. In this report, we demonstrate that combinations of antibiotics and zinc oxide…

THE INTRAGASTRIC PRESENCE OF SPECIFIC AMINO ACIDS IN RAINBOW TROUT IS INVOLVED IN CENTRAL REGULATION OF FOOD INTAKE IN RAINBOW TROUT

In mammals gastric infusion of glutamate and other amino acids such as arginine or lysine, activate brain areas related to food intake control through vagal afferent nerves resulting in an anorectic response. In fish, recent studies have demonstrated that an intraperitoneal injection of leucine and valine reduce food intake, while…

MINOR DIETARY SUPPLEMENTATION WITH A PROTEIN HYDROLYSATE IMPROVES ILEAL MUCOSAL INTEGRITY AND NUTRIENT TRANSPORT, POTENTIALLY MEDIATED BY INCREASED GLP-1/GLP-2 SECRETION

Gastrointestinal functionality is regulated by a complex network of receptors exposed to the luminal environment that sense the presence of nutrients and other chemicals, triggering endocrine and neural pathways that ultimately affect physiological and metabolic responses. This is commonly referred to as “gut chemosensing”. Some of these mechanisms have started…

TARGETING GUT INFLAMMATION IN PIGS WITH THE USE OF OLIVE FRUIT BIOACTIVES POSITIVELY INFLUENCES PIG PERFORMANCE

Prolonged inflammation derived from standard farming procedures drives animals to cytokine-induced anorexia accompanied to a negative energy balance, resulting in reduced animal performance. Previous work showed that the addition of olive fruit bioactives (OFB) in feed was able to reduce inflammation and prevent gut integrity side-effects on a model of…

FEEDING A BIOACTIVE EXTRACT FROM OLEA EUROPAEA TO BROILER CHICKENS EXERTS A POSITIVE IMMUNOREGULATORY EFFECT WITHOUT MAJOR EFFECTS ON GUT MICROBIOT

The present study examined the effects of bioactive compounds from a standardized Olea europaea extract (OE) on gut microbiota composition and immune response in broiler chickens. A total of 3 hundred and 6 1-dold broiler chickens (Ross 308) were randomly allocated in floor pens (6 pens / treatment, with 17…

DIFFERENTIAL ACTION OF TGR5 AGONISTS ON GLP-2 SECRETION AND PROMOTION OF INTESTINAL ADAPTATION IN A PIGLET SHORT-BOWEL MODEL

We previously showed that feeding bile acids can induce glucagon-like peptide 2 (GLP-2) secretion and intestinal growth in parenteral nutrition-fed (PN) piglets. We hypothesize that bile acids function as agonist for the G protein-coupled bile acid receptor 1 (TGR5) expressed in enteroendocrine L cells to induce GLP-2 secretion. Our in…

DETERMINATION OF OPTIMAL INCLUSION LEVEL OF BIOACTIVE OLEA EUROPAEA EXTRACT IN PROMOTING SECRETION OF GLP-1 AND ITS EFFECTS ON GROWTH AND HEALTH IN DAIRY CALVES

A bioactive extract from Olea europaea (OBE) can stimulate secretion of glucagon-like peptide-1 (GLP-1) and GLP-2, through bile acid receptor TGR5. Increasing circulation of GLP-2 promotes beneficial effects on intestinal function, which can be compromised in preruminant calves. The aims of this study was to determine the optimal inclusion level…